In this conversation, Paul Werbos — the mathematician who invented backpropagation, the learning algorithm at the foundation of modern neural networks — explores the territory where artificial intelligence meets the mysteries of consciousness and psi. He speaks to the architecture of mind and brain, a quantum understanding of the universe, and his own encounters with precognition and the questions they raised. Ranging from machine learning to the soul, the noosphere, and the coming life we may share with intelligent machines, he reflects on what a larger science of mind might ultimately include.